amj gastric aspirate in premature infants
نویسندگان
چکیده
Phospholipid analyses in tracheal, hypopharyngeal or gastric aspirates of premature infants have been performed in order to predict or to establish the diagnosis of hyaline membrane disease (HMD) [1, 2, 3, 4, 7]. The predictive value of solely measuring the lecithin/spingomyelin ratio (L/S) in these fluids is controversial. Few studies have included the detection of phosphatidylglycerol (PG), a very specific minor phospholipid of pulmonary surfactant [5, 11]. No information is available as to whether tracheal and gastric aspirates at birth have a different phospholipid composition and thereby a different predictive value.
منابع مشابه
Rapid test for lung maturity, based on spectroscopy of gastric aspirate, predicted respiratory distress syndrome with high sensitivity
AIM Respiratory distress syndrome (RDS) is a major cause of mortality and morbidity in premature infants. By the time symptoms appear, it may already be too late to prevent a severe course, with bronchopulmonary dysplasia or mortality. We aimed to develop a rapid test of lung maturity for targeting surfactant supplementation. METHODS Concentrations of the most surface-active lung phospholipid...
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We have measured lipolytic activity in gastric aspirates obtained at birth in a group of 142 infants. The infants ranged in gestational age from 26 to 41 wk. Lipolytic activity, measured by the hydrolysis of long chain triglyceride ([tri-(3)H]oleate), and expressed as nanomoles FFA per milliliter gastric aspirate per minute was 333+/-66 in 55 small premature infants (gestational age 26-34 wk an...
متن کاملPepsin, a reliable marker of gastric aspiration, is frequently detected in tracheal aspirates from premature ventilated neonates: relationship with feeding and methylxanthine therapy.
OBJECTIVES To determine the frequency of pepsin detection in tracheal aspirate (TA) samples of mechanically ventilated premature neonates and its association with feedings and methylxanthine therapy. PATIENTS AND METHODS Serial TA samples (days 1, 3, 5, 7, 14, 21, 28 and >28 days) were collected from premature neonates receiving ventilatory support. An enzymatic assay with a fluorescent subst...
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